Determination of β-cell function test was used to observe the function of pancreatic β-cell conditions, to help determine the types of diabetes. .....

Determination of β-cell function test was used to observe the function of pancreatic β-cell conditions, to help determine the types of diabetes. Usually include:

(1) insulin release test: 75 grams of oral glucose or steamed 22, Determination of fasting and postprandial plasma insulin levels. Normal fasting insulin value of 5 ~ 15μlU/ml, OGTT after 1 hour and up to fasting 5 ~ 10 times, three hours after the return to fasting levels. Type 1 diabetes patients with a serious lack of insulin secretion, postprandial insulin secretion is also no significant increase; patients with type 2 diabetes early fasting insulin level or slightly higher than normal, late is often reduced postprandial insulin secretion peak of more delays in the 2 ~ 3 hours appear. Advanced type 2 diabetes patients, as a result of pancreatic β-cell failure is already in a state, test results may be similar to type 1 diabetes, insulin determination at this time alone to distinguish between type 1 and type 2 diabetes are no longer justified.

(2) C-peptide release test: C-peptide is endogenous insulin at the time of the last generation, such as molecular dissociation product of normal fasting plasma C-peptide value of 0.8 ~ 4.0μg / L. 1 ~ 2 hours postprandial increase of 4 ~ 5 times, 3 hours after the basic level of return to fasting. The significance of this test and insulin release test the same. The advantage that determination of serum C-peptide could be excluded from the interference of exogenous insulin, and can more accurately reflect its own insulin secretion function.