Insulin analogues (also known as insulin-derivative) is to use artificial means to change the genetic structure of insulin, the insulin and human insu

The concept of insulin analogues
Insulin analogues (also known as insulin-derivative) is to use artificial means to change the genetic structure of insulin, the insulin and human insulin a few amino acid differences, thus leading to its physical and chemical properties change, but without changing its biological Hypoglycemic characteristics. At present, there are mainly two drugs, one is the ultra-short effect of insulin analogues, and the other is ultra-long-acting insulin analogue.
Compared to insulin and insulin analogues What are the advantages of
Insulin analogues compared with human insulin, has many benefits:
1. Take effect quickly and avoid the effect of human insulin takes 30 ~ 60 minutes, 30 minutes must be hors d'administration shortcomings, only 15 minutes neighboring preprandial injection, or in the meal that is at the same time the role of short duration .
2. Closer to the physical therapy, and long-acting insulin analogue joint applications, three meals a day when the injection of short-acting analogues and bedtime glycididazole injection of insulin, diabetes can help to more accurately simulate the normal physiological state of insulin metabolism, in order to maximize blood glucose control in the normal range, and not easy to cause the occurrence of hypoglycemia.
3. Peak onset time and peak postprandial blood glucose simultaneously, and better control of postprandial hyperglycemia.
4. A significant reduction in night-time attack of hypoglycemia. A 518 patients with type 2 diabetes to participate in clinical trials show that on the 1st of the 1st glycididazole NPH insulin efficacy and considerable, but the incidence of hypoglycemia were 31.3% and 40.2%. Another three studies found that a total of 780 type 1 diabetes patients 0 ~ 6:00 of the cases of hypoglycemia, insulin lispro significantly less than human insulin, Meta analysis of 72 patients with two drugs that occurred after injection of low blood sugar reactions, respectively, 102 times and 131 times (P = 0.024).
5. Can reduce the sugar together hemoglobin (HbA1c), to achieve <7 percent target.
6. Injection site of drug absorption than the stability of the changes in individual as well as the differences between individual smaller variability absorbed a very significant improvement. In addition, large doses of insulin injections may be formed in the subcutaneous storage, efficacy and duration difficult to predict, and the recurrence of such a phenomenon rarely analogues.
7. Bedtime glargine injected with the combined use of oral hypoglycemic agents, type 2 diabetes will improve glycemic control, and more than is usually easier to achieve the desired cost-saving goals.
8. Oral adrenocorticotropic hormone deficiencies in patients with diabetes are often dealing with impaired postprandial blood glucose, glucocorticoids can inhibit the secretion of insulin and increase gluconeogenesis, reduce peripheral tissue uptake of glucose. However, insulin analogues may change this drawbacks.
9. Analogs not to activate the insulin-like growth factor receptor 1 (IGF-1), less-mediated multiplier effect.