Wednesday, January 14, 2009

Diabetes is due to lack of insulin secretion in vivo glucose metabolism disorder caused by a disease. Its incidence in our country there are an increa

Diabetes is due to lack of insulin secretion in vivo glucose metabolism disorder caused by a disease. Its incidence in our country there are an increasing number of trends, if not a very good long-term disease control, will happen a variety of complications, such as coronary heart disease, arteriosclerosis, diabetes, kidney disease, will be a serious life-threatening.

At present, the treatment of diabetic diet is still the main, if not sufficient to alleviate the condition. The use of medication, are commonly used insulin injection, as well as a sugar Nanjing, Jiangtang Ling, glibenclamide, urea and other sulfochlorophenol C oral hypoglycemic agents, including insulin stronger role, mainly for heavy patients, oral hypoglycemic agents only in light and medium-sized patients.

In addition to master the indications, the combination can not be taken lightly, or else they will drop efficiency, failure, and even exacerbated the disease. Certain drugs itself the role of elevated blood sugar, such as prednisone, triamcinolone and cortisone acetate, hydrocortisone and dexamethasone, betamethasone-pui, and so on, can increase the glycogen yuan, to blood glucose or high. If they were combined with hypoglycemic agents may have against the role of the effect of lowering. Another example is furosemide, Lee uric acid, chlorthalidone, chlorothiazide Dihydroartemisinin and so on, can inhibit the secretion of insulin, so that elevated blood sugar, or even coma. Another example Chloropropionic Acid, non-Flanagan,泰尔登, perphenazine, trifluoperazine, as well as iodine A security, such as thyroid-stimulating hormone, also face a similar situation, it is not appropriate combination.

There are women of childbearing age in the application of estrogen, progesterone oral contraceptives, and hypoglycemic agents have reduced the role of efficiency, will be diverted to use other contraceptives. Some drugs and oral hypoglycemic agents or insulin combined, can interfere with each other, the impact of efficacy, toxicity and even.

When suffering from tuberculosis in diabetic patients, if a sugar Nanjing (D860) and isoniazid, rifampicin combination, which will lead to liver enzyme secreted more drugs to speed up a sugar metabolism and excretion of Nanjing, so that the deterioration of diabetes can lead to coma, it will be diverted to use streptomycin, nitrogen thiourea of aminosalicylate sodium in the treatment of tuberculosis.

Diabetics suffering from high blood pressure when insulin injections and taking reserpine will hinder the release of norepinephrine, so that lower blood sugar, thereby enhancing the role of insulin, hypoglycemia reaction can be, so to switch to Jiangyaling or foul Indus, Prunella, Siegesbeckiae grass, chrysanthemum, and so the treatment of hypertension.

Diabetes due to intestinal infection use of chloramphenicol, which can inhibit liver enzymes drugs, so that slow down the metabolism of oral hypoglycemic agents and easy to cause hypoglycemia. According to reports, patients daily oral chloramphenicol 2 grams, once a 10 days, will enable the half-life of a sugar Nanjing extended to five hours from 15 hours, blood drug concentration per 100 ml from 7.5 mg to 14 mg, A substantial boost to the sugar Nanjing Hypoglycemic efficacy and side effects to the disease is exacerbated. Therefore, in the application of chloramphenicol at the same time, will be diverted to use Jiangtang Ling or Jiangtang tablet metformin treatment of diabetes.

There Guanxin ping (Clofibrate) and stuffy cola, gifted down Nanjing (Department of antihypertensive agents), Nandrolone, will cause low blood sugar, should avoid sharing.

Diabetes who have sinus tachycardia and hypertension, if glybenclamide combined with propranolol, the role of glybenclamide strong and fast, propranolol can to increase insulin secretion, at the same time cover up the low blood sugar caused by an increase in heart rate signs, it is not appropriate with the service.

Bronchitis and diabetes patients, if a sugar Nanjing and sulfa drug sulfamethoxazole merger applications, the blood will increase the concentration of hypoglycemic agents may be hypoglycemia, so the second drug should be used interval.

People are suffering from diabetes Thrombophlebitis when, if a sugar and Nanjing dicoumarol with clothes, a sugar replacement would prefer the latter, its concentration increases, causing bleeding; and dicoumarol A sugar can inhibit the Nanjing Metabolism and excretion, from its half-life of five hours extended to 18 hours, easy hypoglycemia. Glybenclamide, methyl C gland with GC dicoumarol also face a similar situation, it is not appropriate combination.

Diabetics suffer from rheumatic fever when, if aspirin and glibenclamide, a sugar Nanjing, such as hydrazine sulfochlorophenol C combined with aspirin replacement both oral hypoglycemic agents, so that plasma concentration increased, but also hypoglycemic agents can slow down the metabolism and excretion, Third aspirin itself Jiangtang role, resulting in hypoglycemia coma, it is advisable to switch to naproxen treatment of rheumatism.

In addition, tetracycline, oxytetracycline, gentamicin, kanamycin with Jiangtang Ling combined, can produce a large number of lactic acid, causing acidosis, and even life-threatening, it will be diverted to other anti-bacterial medication.

Need to be emphasized that during the diabetes drugs, alcohol is extremely harmful, alcoholism drugs inhibit the liver enzymes, so that insulin and oral hypoglycemic agents cause severe low blood bran, and even death; a small amount of alcohol on many occasions enzyme secretion can promote drugs to speed up the metabolism of hypoglycemic agents to reduce the effect. At the same time, the middle of alcohol metabolite acetaldehyde oxidation, such as by the effects of hypoglycemic agents, can increase the blood concentration of acetaldehyde, resulting in toxicity, such as the pulsating headache, nausea and vomiting, sweating and thirst, tachycardia, shortness of breath, blood pressure decreased, and even shock, it is necessary temperance.

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