Wednesday, January 14, 2009

Insulin is the body of pancreatic β-cell secretion of the body the only hypoglycemic hormone. Insulin resistance refers to the tissues around the body

The concept of insulin
Insulin is the body of pancreatic β-cell secretion of the body the only hypoglycemic hormone. Insulin resistance refers to the tissues around the body less sensitive to insulin, organization is not sensitive to insulin, peripheral organizations such as muscle, fat to insulin to promote the role of glucose uptake occurred in the resistance.
The physiological role of insulin
Insulin is the body's hormone only lowering blood glucose and only at the same time promote glycogen, fat, protein synthesis of the hormone. Mechanism mechanisms are receptor tyrosine kinase. There is regulation of glucose metabolism, regulation of fat metabolism, protein metabolism, such as the role of regulator.
Factors that affect insulin secretion
(1) blood glucose concentration of insulin secretion of the most important factor. Oral or intravenous glucose, the insulin release was two-phase reaction. Early rapid phase, the portal vein plasma insulin that is, within two minutes in the highest value, then decreased rapidly; delay in the slow-phase, 10 minutes after the plasma insulin level has been edging higher, has continued for more than one hours. Early rapid phase shows stored glucose to insulin release, the delay shows that the slow-phase synthesis of insulin and proinsulin changing insulin.

(2) eat more food containing protein, the blood concentration of amino acids increased, also increased insulin secretion. Arginine, lysine, leucine and phenylalanine have a strong role to stimulate insulin secretion.

(3) after meals to increase gastrointestinal hormone could promote insulin secretion, such as gastrin, secretin, gastric inhibitory peptide, vasoactive intestinal peptide are stimulated insulin secretion.

(4) freedom of nerve function could affect the secretion of insulin. Stimulation of vagus nerve to promote insulin secretion; sympathetic excited when inhibit insulin secretion.

The study found the prevalence of insulin resistance in type 2 diabetes, accounting for almost 90%, may be the incidence of type 2 diabetes one of the main factors.

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