intensive therapy has been the level of blood sugar control HbA1c7.0% of many diabetes treatment guidelines recommended target. At present this goal

United Kingdom prospective study on diabetes (UKPDS)
United Kingdom prospective study of diabetes (UKPDS) began in 1977, the study was designed to answer a basic question: In patients with type 2 diabetes, the enhanced blood glucose control can reduce the risk of complications of diabetes.

A total of 5102 cases of newly diagnosed type 2 diabetes were selected, in the three months of dietary treatment, 4209 cases of patients were randomly assigned to the group. In addition to a small number of obese patients were randomly assigned to the use of metformin treatment, a total of 342 cases of patients, other patients were randomly assigned to receive conventional treatment of 1138 cases, or 2729 cases of intensive therapy. Conventional treatment group mainly lifestyle intervention, poor blood sugar control were randomly assigned to the sulfonylurea, insulin or metformin, obesity, the treatment group; the strengthening of the treatment group in the beginning of the study, randomly assigned to receive 1156 cases of insulin or sulfonylureas 1573 Cases of treatment, for the purpose of fasting blood glucose control in 6mmol / L, 108mg/dl following. Acceptance of sulfonylurea drug treatment patients, 339 cases ultimately need insulin therapy because of poor blood sugar control during the study period; In addition, there are 268 cases of patients with sulfonylurea accept as a result of poor blood sugar control services need to metformin treatment. UKPDS follow-up study of patients with an average of 10 years (53,000 patient years).

United Kingdom prospective study of diabetes (UKPDS) major findings
UKPDS study in type 2 diabetes study of great significance. Its main findings included the following:

Intensive treatment can reduce the occurrence of complications related to the risk of microvascular complications can reduce the risk of vascular complications in the context, can reduce the risk of myocardial infarction. Intensive therapy can reduce the need for cataract surgery patients ratio. And conventional treatment group compared to the first 12 years in the study, the intensive therapy can retinopathy and albuminuria incidence decreased significantly to the risk of decreased 21% P = 0.015 and 33% P = 0.000054. In the intensive therapy group and between the conventional treatment group, HbA1c mean absolute difference of 0.9%, or intensive therapy group HbA1c less than 11 percent of conventional treatment group.

Because type 2 diabetes is a progressive disease, with the β-cell function occurred in the sexual failure, in many diabetic patients, in order to maintain good blood sugar control, the need for the use of insulin therapy, in 6 years after the beginning of the study, about 50% The patients need insulin therapy. In addition, with the extension of course, insulin requirements have also increased.

United Kingdom prospective study of diabetes (UKPDS) the main conclusions
UKPDS study confirmed that type 2 diabetes is a serious sexual diseases, in the 15-year study period, HbA1c levels and fasting blood glucose levels continued to rise, indicating that β-cell function of sexual failure.

UKPDS study clearly, in type 2 diabetes patients, to improve glycemic control of intensive intervention in the treatment of diabetes can reduce the risk of late complications. On this point and early in patients with type 1 diabetes conducted research DCCT results.

Type 2 diabetes often need to strengthen the treatment of joint use of different drugs. UKPDS received from the very clear conclusion is that, due to disease progression, in order to maintain good long-term glycemic control, many patients with diabetes will need insulin therapy.

In the UKPDS study, intensive therapy has been the level of blood sugar control HbA1c7.0% of many diabetes treatment guidelines recommended target. At present this goal in most patients with type 2 diabetes failed to be realized. Therefore, we should strengthen the control of blood sugar in diabetic patients