Wednesday, January 14, 2009

is generally believed that abnormal glucose tolerance (IGT) is the performance of pre-diabetes, especially type 2 diabetes. It has been reported,.....

At present, is generally believed that abnormal glucose tolerance (IGT) is the performance of pre-diabetes, especially type 2 diabetes. It has been reported, IGT patients in 5 to 10 years, there were 1 / 3 can be transformed into diabetic patients, 1 / 3 return to normal, 1 / 3 will remain unchanged. However, between the different races in different regions of the vesting IGT is also different.
IGT is not only to develop into a transitional stage of diabetes, type 2 diabetes prevention is the final gateway. IGT is why the period of treatment is to intervene to prevent type 2 diabetes the key!

Play an important role in behavioral intervention
Behavioral intervention in a number of small-scale prospective study of the effect has been considerable.

Sweden to a group of middle-aged men to intervene in the treatment of patients with IGT - diet plus exercise therapy: dietary requirements to reduce the sugar and fat, increase complex carbohydrate and dietary fiber, overweight require low-calorie to weight loss; exercise therapy are at the beginning of 6 ~ December collective exercise in future to encourage sports clubs at home or training, by the 5-year follow-up, intervention treatment group, weight loss, diabetes conversion rate was only 11 percent; while the control group reduced body weight, 21 percent into a diabetic. In recent years, Finland and the United States has conducted large-scale, multi-center, long-term eating and physical activity intervention, achieved a very good prevention of type 2 diabetes results, especially for middle-aged and older, than the drug metformin intervention more effective.

Therefore, the change in IGT's way of life, formulate a reasonable balance between a healthy diet, perseverance to carry out appropriate physical activity, obesity given to low-fat diet low heat so that it returned to normal weight range, particularly through exercise and diet to reduce abdominal fat It is the basic therapy to combat IGT.

Choice of drug prevention and treatment of IGT
While lifestyle changes to combat the effects of IGT significantly, but its implementation is not an easy task, so the drug intervention should also be taken seriously. IGT intervention for treatment of drugs should be subject to the following conditions: 1. To improve glucose tolerance, not cause hypoglycemia. 2. The best to reduce the level of plasma insulin, at least not increased. 3. Not to provoke the islet B cells do not increase their burden, and its function in advance to avoid a recession. 4. To improve dyslipidemia. 5. Not to increase the weight. 6. Safe, non-serious adverse reactions. Has been the early pre-testing, ongoing large-scale intervention trial IGT There are several kinds of drugs:

1.α-glucosidase inhibitors - acarbose: the characteristics of acarbose for the delay of intestinal carbohydrate absorption, reduce postprandial hyperglycemia, while reducing postprandial hyperinsulinemia, reducing postprandial glycerol Third, higher esters and can mobilize the type of intestinal glucagon-like peptide -1 (GLP-1), the latter will enable IGT in B cells of the minor defects in insulin secretion was restored. α-Glucosidase inhibitors mainly bloating side effects can be started using a small dose and gradually increase the volume so that the intestinal tract, the next paragraph of the α-Glucosidase activity gradually induced out, so can significantly reduce the intestinal side effects.

2. Metformin: This drug can reduce blood sugar, insulin at the same time also dropped. Its mechanism may be improved insulin sensitivity and reduce the intestinal absorption of sugar. Metformin does not increase the weight of high blood cholesterol also have a role. The major adverse drug reaction diarrhea. Objects in the choice of treatment should pay attention to avoid lactic acidosis possibilities.

3. Thiazolidinediones: previously tried troglitazone, troglitazone can improve insulin resistance, so that blood sugar drop, drop in blood insulin, triglyceride decreased, without increasing weight. Although see troglitazone progress in the prevention of diabetes high-risk groups to the effect of type 2 diabetes, but because of its liver toxicity, and all were forced to suspend clinical trials, after the switch to the liver toxicity of rosiglitazone, a preventive effect similar.

General population should be actively screening
Due to the high incidence of IGT is generally asymptomatic, the patient will not take the initiative to visit and easy to translate into type 2 diabetes, but also prone to cardio-cerebral vascular diseases, such as big, and still can not rule out the possibility of occurrence of microvascular disease. Therefore, a positive attitude is very important crowd detection IGT, particularly in obesity and overweight people should also pay due attention, regular physical examination, not only to be measured fasting blood glucose, postprandial blood glucose test also found that questions should be done glucose tolerance test ( OGTT).

1 comment:

  1. Drug intervention offers sober living Los Angeles and Los Angeles drug rehab programs.

    ReplyDelete